Creating mice with targeted disruptions in protooncogenes and homeobox genes, NIH Director's Lecture given May 21, 1992

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Publication Type audio
School or College School of Medicine; College of Science
Department Human Genetics; Oncological Sciences; Biology
Program Institute of Human Genetics. Howard Hughes Medical Institute.
Creator Capecchi, Mario R.
Title Creating mice with targeted disruptions in protooncogenes and homeobox genes, NIH Director's Lecture given May 21, 1992
Date 1992
Description This is an audio transcript of a 1 hour, 2 minutes and 12 seconds lecture given at the National Institutes of Health by Mario Capecchi on 1992/05/21. Beginning with a short summary of the mechanics of gene transfer and the ability to create germline chimera with mutations that become hereditary within a line of mice, Capecchi discusses the investigation of two lines of basic developmental genes, protooncogenes and homoebox genes. Creation of lines of knockout mice allows the identification of the function of the actual gene as well as the various expression patterns that result. Other key concepts included in this lecture are monozygote and homozygote developmental differences.
Type Sound
Publisher National Institutes of Health
Subject Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Mutagenesis; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype
Subject MESH Genetic Research; Gene Targeting; Mice, Knockout; DNA Mutational Analysis; Recombination, Genetic; Gene Expression Regulation, Developmental
Language eng
Rights Management (c) National Institutes of Health
Identifier ir-main,1830
ARK ark:/87278/s6sq9j4q
Setname ir_uspace
Date Created 2012-07-31
Date Modified 2012-07-31
ID 707911
Reference URL https://collections.lib.utah.edu/ark:/87278/s6sq9j4q
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