Structure of vardenafil in the active site of PDE5

Update item information
Publication Type Multimedia
School or College College of Pharmacy
Department Pharmacology & Toxicology
Creator Blumenthal, Donald K.
Title Structure of vardenafil in the active site of PDE5
Date 2006-07-14
Description PyMol file (725 KB): http://ir.utah.edu/blumenthal/PyMol/PDE5_Vardenafil.pse

Download PyMol software to view this file. Available for free educational use: http://pymol.sourceforge.net

Quicktime Movie--High Resolution (4 MB): http://stream.lib.utah.edu/index.php?c=details&id=9288

Quicktime Movie--Medium Resolution (1 MB): http://stream.lib.utah.edu/index.php?c=details&id=9291

iPod (490 KB): http://stream.lib.utah.edu/index.php?c=details&id=9293

The active site of human PDE5 is shown as a ribbon cartoon with key amino acid sidechains and vardenafil represented as stick images (stick coloring is according to element: C = white, N = blue, O = red, S = orange). The zinc (blue-grey) and magnesium (green) ions in the active site are represented as spheres. The amino-terminal cyclin fold domain (residues 537-678) is represented as an orange ribbon, the linker domain (residues 679-725) is represented as a blue ribbon, and the carboxy-terminal helical bundle domain (726-860) is represented as a cyan ribbon. The active site sidechains shown are Tyr612, Tyr664, Val782, Ala783, Phe786, Leu804, Met816, Gln817, and Phe820. The animation is based on the x-ray crystal structure of PDE5 in complex with vardenafil (PDB id:1UHO) and was prepared using PyMol
Publisher The McGraw-Hill Companies http://www.accessmedicine.com/resourceToc.aspx?resourceID=28
Subject Levitra; Phosphodiesterase inhibitors; PDE; Enzymes; Intracellular cyclic nucleotide-mediated signaling; 110634
Language eng
Bibliographic Citation Stehlik, Josef; Movsesian, Matthew A. Update: PDE5 inhibition in Cardiovascular Disease. Goodman & Gilman's The Pharmacological Basis of Therapeutics, (11th Ed). Laurence L. Brunton (ed). Retrived September 5, 2006 from http://www.accessmedicine.com/updatesContent.aspx?aid=1000904
Rights Management Copyright ©2006 The McGraw-Hill Companies. All rights reserved.
Format Medium image/jpeg (visual file)
Identifier ir-main,371
ARK ark:/87278/s6f486vn
Setname ir_uspace
Date Created 2012-07-30
Date Modified 2012-12-12
ID 707802
Reference URL https://collections.lib.utah.edu/ark:/87278/s6f486vn
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