Na-H exchange inhibition with Cariporide limits functional impairment caused by repetitive ischemia

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Publication Type Journal Article
School or College College of Health
Department Nutrition
Creator Symons, John David
Other Author Correa, Steven D.; Schaefer, Saul
Title Na-H exchange inhibition with Cariporide limits functional impairment caused by repetitive ischemia
Date 1998
Description Intracellular calcium ([Ca]i) overload on reperfusion may be one of the mechanisms responsible for ischemia-induced regional myocardial dysfunction. Because inhibiting the Na-H exchanger (NHE) limits intracellular sodium ([Na]i) and subsequent [Ca]i accumulation, we hypothesized that NHE inhibition would attenuate regional dysfunction in response to 25 cycles of ischemia (I, 2-min) and reperfusion (R, 8-min) of the left circumflex coronary artery (LCx) in conscious swine. Six animals were instrumented to measure arterial pressure, regional myocardial blood flow (colored microspheres), systolic wall thickening (WTh) in the normally perfused (left anterior descending, LAD) and LCx regions (sonomicrometry), LCx blood flow velocity (Doppler), and to reversibly occlude the LCx (hydraulic occluder).
Type Text
Publisher Wolters Kluwer (LWW)
Volume 32
Issue 6
First Page 853
Last Page 862
Subject Reperfusion; intracellular calcium; conscious pigs
Language eng
Bibliographic Citation Symons, J. D., Correa, S. D., Schaefer, S. (1999). Na-H exchange inhibition with Cariporide limits functional impairment caused by repetitive ischemia. Journal of Cardiovascular Pharmacology, 32(6), 853-62.
Rights Management (c)Lippincott, Williams & Wilkins
Format Medium application/pdf
Format Extent 3,511,595 bytes
Identifier ir-main,1942
ARK ark:/87278/s6cg07sz
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 707190
Reference URL https://collections.lib.utah.edu/ark:/87278/s6cg07sz
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