Refutation of the general single locus model for the etiology of schizophrenia

Update item information
Publication Type Journal Article
School or College College of Social & Behavioral Science
Department Anthropology
Creator O'Rourke, Dennis H.
Other Author Gottesman, I. I.; Suarez, B. K.; Rice, J.; Reich, T.
Title Refutation of the general single locus model for the etiology of schizophrenia
Date 1982
Description All published studies on the familial incidence of schizophrenia appropriate for testing the applicability of the general single-locus two-allele model are examined under the assumption of a unitary etiology for all schizophrenia. We show that the single major locus model is inadequate to predict the incidence in four classes of relatives of schizophrenic probands (parents, siblings, monozygotic, and dizygotic cotwins). In addition, the observed proportion of affected offspring from dual matings differ significantly from the model's prediction. The lack of an overall fit between the published familial distributions and the monogenic model suggests that a single major locus is insufficient for the etiology of schizophrenia. Further efforts in examining multifactorial models, mixed models, and other transmission models may be fruitful.
Type Text
Publisher University of Chicago Press
Volume 34
Issue 4
First Page 630
Last Page 649
Subject Genetics; Diseases in Twins; Chromosome Mapping
Subject MESH Models, Genetic; Schizophrenia
Language eng
Bibliographic Citation O'Rourke, D.H., Suarez, B. K., Rice, J., & Reich, T. (1982). Refutation of the general single locus model for the etiology of schizophrenia. American Journal of Human Genetics, 34(4), 630-49.
Rights Management (c) University of Chicago Press
Format Medium application/pdf
Format Extent 1,976,730 bytes
Identifier ir-main,11135
ARK ark:/87278/s6ng5881
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 706889
Reference URL https://collections.lib.utah.edu/ark:/87278/s6ng5881