| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Capecchi, Mario R.; Thomas, Kirk R. |
| Other Author |
Folger, Kim R. |
| Title |
High frequency targeting of genes to specific sites in the mammalian genome |
| Date |
1986 |
| Description |
We corrected a defective gene residing in the chromosome of a mammalian cell by injecting into the nucleus copies of the same gene carrying a different mutation. We determined how the number, the arrangement, and the chromosomal position of the integrated gene, as well as the number of injected molecules influence the gene-targeting frequency. |
| Type |
Text |
| Publisher |
MIT Press |
| Volume |
44 |
| First Page |
419 |
| Last Page |
428 |
| Subject |
Homologous recombination; Mutant genes; Mammalian genome |
| Subject LCSH |
Gene targeting; Recombinant DNA; Mutation (Biology) |
| Language |
eng |
| Bibliographic Citation |
Thomas, K. R., Folger, K. R., & Capecchi, M. R. (1986). High frequency targeting of genes to specific sites in the mammalian genome. Cell, 44, 419-28. |
| Rights Management |
(c) MIT Press http://mitpress.mit.edu/ |
| Format Medium |
application/pdf |
| Format Extent |
2,488,700 bytes |
| Identifier |
ir-main,8972 |
| ARK |
ark:/87278/s67p9h1n |
| Setname |
ir_uspace |
| ID |
706809 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s67p9h1n |
