Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Frels, William I.; Bluestone Jeffery A; Hodes, Richard J; Singer Dinah S.
Title Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice.
Date 1985-05-03
Description A porcine class I major histocompatibility complex (SLA) gene has been introduced into the genome of a C57BL/10 mouse. This transgenic mouse expressed SLA antigen on its cell surfaces and transmitted the gene to offspring, in which the gene is also expressed. Skin grafts of such transgenic mice were rejected by normal C57BL/10 mice, suggesting that the foreign SLA antigen expressed in the transgenic mice is recognized as a functional transplantation antigen.
Type Text
Publisher American Association for the Advancement of Science (AAAS)
Volume 228
Issue 4699
First Page 577
Last Page 580
Subject Genetic Engineering; Graft Rejection; Mice, Inbred C57BL
Subject MESH Major Histocompatibility Complex; Nucleic Acid Hybridization; Skin Transplantation
Language eng
Bibliographic Citation Science. 1985 May 3;228(4699):577-80. Frels WI, Bluestone JA, Hodes RJ, Capecchi MR, Singer DS. Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. Retrieved on November 1 2006 from http://www.sciencemag.org/cgi/reprint/228/4699/577.
Rights Management copyright © 1985 American Association for the Advancement of Science. All Rights Reserved.
Format Medium application/pdf
Identifier ir-main,525
ARK ark:/87278/s6qj81v6
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 706460
Reference URL https://collections.lib.utah.edu/ark:/87278/s6qj81v6
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