Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. a comparison between staurosporine and tamoxifen

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Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Couldwell, William T.
Other Author Baltuch, Gordon H.; Villemure, Jean-Guy; Yong, Voon Wee
Title Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. a comparison between staurosporine and tamoxifen
Date 1993
Description WE HAVE PREVIOUSLY demonstrated that the proliferation of established human glioma cell lines correlated with protein kinase C (PKC) activity and that a relatively selective PKC inhibitor, staurosporine, inhibits glioma cell proliferation. The purpose of this study was to determine whether low-passage glioma cell lines were also sensitive to staurosporine and to compare the antimitotic effects of staurosporine with tamoxifen, an antiestrogen with a known PKC inhibitory effect presently being investigated in the treatment of recurrent glioma. We measured the effects of treatment with staurosporine or tamoxifen on the proliferation rate of five established glioma cell lines (A172, U251, U87, U373, U563) and four low-passage glioma cell lines.
Type Text
Publisher Wolters Kluwer (LWW)
Volume 33
Issue 3
First Page 495
Last Page 501
Subject Staurosporin; Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Glioma cell lines
Subject LCSH Protein kinases; Gliomas; Brain -- Cancer
Language eng
Bibliographic Citation Baltuch, G. H., Couldwell, W. T., Villemure, J.-G., & Yong, V. W. (1993). Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. a comparison between staurosporine and tamoxifen. Neurosurgery, 33(3), 495-501.
Rights Management (c) Wolters Kluwer (LWW)
Format Medium application/pdf
Format Extent 692,517 bytes
Identifier ir-main,12506
ARK ark:/87278/s63f577v
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 706342
Reference URL https://collections.lib.utah.edu/ark:/87278/s63f577v
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