Publication Type |
Journal Article |
School or College |
School of Medicine |
Department |
Neurosurgery |
Creator |
Couldwell, William T. |
Other Author |
Weiss, Martin H. |
Title |
Defining postoperative values for successful resection of prolactinomas |
Date |
1996 |
Description |
We, as other authors, have noted that late relapse of hyperprolactinemia following apparent successful adenomectomy in women harboring microprolactinomas is not rare.[1-3] On retrospective review of a series of tumors treated at the University of Southern California teaching hospitals, we have found that the immediate postoperative prolactin level may be predictive of late recurrence of hyperprolactinemia.[4] It is our routine to ascertain prolactin levels at 3 days and 6 weeks postoperatively. Of 133 patients undergoing microadenomectomy who had 3-day postoperative prolactin levels of less than 10 μg/L (the vast majority of these were less than 3 μg/L), 132 or 99% had prolactin levels of less than 20 μg/L at their 6-week follow-up examination. At 5 years postoperatively, 130 (98%) of the original 133 patients still had normal prolactin levels. However, of 43 patients who had 3-day postoperative prolactin levels in the range of 10 to 20 μg/L, only 32 (74%) had prolactin levels in the normal range at 6 weeks postoperatively, and only five (16%) of this group of 32 patients had normal prolactin levels at 5-year follow-up review. Therefore, although 18% of patients who have a normal postoperative prolactin level at 6 weeks will develop recurrent hyperprolactinemia when followed for 5 years, only three (7%) of 41 represent patients with immediate prolactin levels of less than 10 μg/L, whereas the remainder were in the group with immediate postoperative prolactin levels in the 10 to 20 μg/L range. |
Type |
Text |
Publisher |
American Association of Neurological Surgeons (AANS) |
Volume |
1 |
Issue |
1 |
First Page |
e9 |
Subject |
Hyperprolactinemia; Microadenoma; Prolactin |
Subject LCSH |
Hyperprolactinemia; Prolactinoma; Pituitary gland -- Diseases |
Subject MESH |
Pituitary Neoplasms |
Language |
eng |
Bibliographic Citation |
Couldwell, W. T., & Weiss, M. H. (1996). Defining postoperative values for successful resection of prolactinomas. Neurosurgical Focus, 1(1), e9. |
Rights Management |
(c) American Association of Neurological Surgeons |
Format Medium |
application/pdf |
Format Extent |
26,686 bytes |
Identifier |
ir-main,12555 |
ARK |
ark:/87278/s6b85spr |
Setname |
ir_uspace |
ID |
706287 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6b85spr |