Defining postoperative values for successful resection of prolactinomas

Update item information
Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Couldwell, William T.
Other Author Weiss, Martin H.
Title Defining postoperative values for successful resection of prolactinomas
Date 1996
Description We, as other authors, have noted that late relapse of hyperprolactinemia following apparent successful adenomectomy in women harboring microprolactinomas is not rare.[1-3] On retrospective review of a series of tumors treated at the University of Southern California teaching hospitals, we have found that the immediate postoperative prolactin level may be predictive of late recurrence of hyperprolactinemia.[4] It is our routine to ascertain prolactin levels at 3 days and 6 weeks postoperatively. Of 133 patients undergoing microadenomectomy who had 3-day postoperative prolactin levels of less than 10 μg/L (the vast majority of these were less than 3 μg/L), 132 or 99% had prolactin levels of less than 20 μg/L at their 6-week follow-up examination. At 5 years postoperatively, 130 (98%) of the original 133 patients still had normal prolactin levels. However, of 43 patients who had 3-day postoperative prolactin levels in the range of 10 to 20 μg/L, only 32 (74%) had prolactin levels in the normal range at 6 weeks postoperatively, and only five (16%) of this group of 32 patients had normal prolactin levels at 5-year follow-up review. Therefore, although 18% of patients who have a normal postoperative prolactin level at 6 weeks will develop recurrent hyperprolactinemia when followed for 5 years, only three (7%) of 41 represent patients with immediate prolactin levels of less than 10 μg/L, whereas the remainder were in the group with immediate postoperative prolactin levels in the 10 to 20 μg/L range.
Type Text
Publisher American Association of Neurological Surgeons (AANS)
Volume 1
Issue 1
First Page e9
Subject Hyperprolactinemia; Microadenoma; Prolactin
Subject LCSH Hyperprolactinemia; Prolactinoma; Pituitary gland -- Diseases
Subject MESH Pituitary Neoplasms
Language eng
Bibliographic Citation Couldwell, W. T., & Weiss, M. H. (1996). Defining postoperative values for successful resection of prolactinomas. Neurosurgical Focus, 1(1), e9.
Rights Management (c) American Association of Neurological Surgeons
Format Medium application/pdf
Format Extent 26,686 bytes
Identifier ir-main,12555
ARK ark:/87278/s6b85spr
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-11-30
ID 706287
Reference URL https://collections.lib.utah.edu/ark:/87278/s6b85spr
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