Neurotransmitter properties of the newborn human retina.

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Publication Type Journal Article
School or College School of Medicine
Department Ophthalmology
Creator Frederick, Jeanne M.
Other Author Hollyfield, Joe g.; Rayborn, Mary E.
Title Neurotransmitter properties of the newborn human retina.
Date 1983
Description Human retinal tissue from a newborn was examined autoradiographically for the presence of highaffinity uptake and localization of the following putative neurotransmitters: dopamine, glycine, GAB A, aspartate, and glutamate. In addition, the dopamine content of this newborn retina was measured by high pressure liquid chromatography. Our study reveals that specific uptake mechanisms for 3Hglycine, 3H-dopamine, and 3H-GABA are present at birth. However, the number and distribution of cells labeled with each of these 3H-transmitters are not identical to those observed in adult human retinas. Furthermore, the amount of endogenous dopamine in the newborn retina is approximately V20 the adult level. Photoreceptor-specific uptake of 3H-glutamate and 3H-aspartate are not observed. These findings indicate that, while some neurotransmitter-specific properties are present at birth, significant maturation of neurotransmitter systems occurs postnatally.
Type Text
Publisher Association for Research in Vision and Ophthalmology
Volume 24
Issue 7
First Page 893
Last Page 897
Subject Newborn; Human Retina; Neurotransmitter Properties; Photoreceptors
Subject MESH Retina; Photoreceptors; Dopamine; Glycine; Infant, Newborn; Retinal Degeneration
Language eng
Bibliographic Citation Hollyfield JG, Frederick JM, Rayborn ME. (1983). Neurotransmitter properties of the newborn human retina. Invest Ophthalmol Vis Sci, 24(7), 893-7.
Rights Management (c) Association for Research in Vision and Ophthalmology
Format Medium application/pdf
Identifier ir-main,1789
ARK ark:/87278/s69s28jg
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 706204
Reference URL https://collections.lib.utah.edu/ark:/87278/s69s28jg
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