Endotoxin enhancement as a possible etiology of early-onset group B beta-hemolytic streptococcal sepsis in the newborn.

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Publication Type Journal Article
School or College School of Medicine
Department Pediatrics; Obstetrics & Gynecology
Creator Varner, Michael W.
Other Author Schlievert, Patrick M.; Galask, Rudolph P.
Title Endotoxin enhancement as a possible etiology of early-onset group B beta-hemolytic streptococcal sepsis in the newborn.
Date 1983-05
Description Group B streptococcal cells, either viable or heat-killed, contain a substance that induced fever in rabbits with maximal responses occurring four hours after intravenous injection. In contrast, supernatant fluids failed to induce significant fever. Group B streptococcal cells also enhanced host susceptibility to lethal shock by endotoxin as much as 40,000-fold. A graph of log streptococcal cell dose used for pretreatment versus log LD50 endotoxin gave a straight line with a slope of approximately -1. Rabbits that received both streptococcal cells and endotoxin showed initial fever followed by hypothermia, labored breathing, watery diarrhea, evidence of vascular collapse, and finally death. Animals that received streptococcal cells or endotoxin alone showed only fevers and mild diarrhea. A possible theory for the cause of death in the neonate infected with group B streptococci is presented.
Type Text
Publisher Lippincott, Williams & Wilkins
Volume 61
Issue 5
First Page 588
Last Page 592
Subject Newborns; Endotoxins; Group B Beta-Hemolytic Streptococcal Sepsis
Subject MESH Streptococcal Infections; Shock, Septic; Drug Synergism; Endotoxins
Language eng
Bibliographic Citation Schlievert PM, Varner MW, Galask RP. Endotoxin enhancement as a possible etiology of early-onset group B beta-hemolytic streptococcal sepsis in the newborn. Obstet Gynecol. 1983 May;61(5):588-92. Retrieved on April 30th, 2007 from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=Display&DB=pubmed
Rights Management Copyright © Wolters Kluwer, Obstetrics and Gynecology, 61, 588-92, 1983
Format Medium application/pdf
Identifier ir-main,1023
ARK ark:/87278/s6611hsm
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 705820
Reference URL https://collections.lib.utah.edu/ark:/87278/s6611hsm
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