| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M. |
| Other Author |
Ferro, Ari M.; Higgins, N. Patrick |
| Title |
Poly(ADP-ribosylation) of a DNA topoisomerase |
| Date |
1983 |
| Description |
A DNA topoisomerase activity, copurifying with poly(ADP-ribose) synthetase from calf thymus, >95% inhibited if extensive poly(ADP-ribosylation) is allowed to occur. The inhibited DNA topoisomerase, which has drastically different elution properties on hydroxylapatite, can be reactivated by mild alkaline treatment. These results are consistent with a poly(ADP-ribosylation) of the DNA topoisomerase and covalent attachment of the poly(ADP-ribose) moieties to the topoisomerase by alkali-labile bonds. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
258 |
| Issue |
10 |
| First Page |
6000 |
| Last Page |
6003 |
| Subject |
Nicotinic acid; ADP-ribosylation; Turnover cycle; Synthetases |
| Subject LCSH |
DNA topoisomerases; Pyridine nucleotides; NAD (Coenzyme); Ligases |
| Language |
eng |
| Bibliographic Citation |
Ferro, A. M., Higgins, N. P., & Olivera, B. M. (1983). Poly(ADP-ribosylation) of a DNA topoisomerase. Journal of Biological Chemistry, 258(10), 6000-3. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
1,775,393 bytes |
| Identifier |
ir-main,8186 |
| ARK |
ark:/87278/s6bp0m6n |
| Setname |
ir_uspace |
| ID |
705429 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6bp0m6n |
