Hoxc13 mutant mice lack external hair

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Godwin, Alan R.
Title Hoxc13 mutant mice lack external hair
Date 1998-01-01
Description Hox genes are usually expressed temporally and spatially in a colinear manner with respect to their positions in the Hox complex. Consistent with the expected pattern for a paralogous group 13 member, early embryonic Hoxc13 expression is found in the nails and tail. Hoxc13 is also expressed in vibrissae, in the filiform papillae of the tongue, and in hair follicles throughout the body; a pattern that apparently violates spatial colinearity. Mice carrying mutant alleles of Hoxc13 have been generated by gene targeting. Homozygotes have defects in every region in which gene expression is seen. The most striking defect is brittle hair resulting in alopecia (hairless mice). One explanation for this novel role is that Hoxc13 has been recruited for a function common to hair, nail, and filiform papilla development.
Type Text
Publisher Cold Spring Harbor Lab Press
Volume 12
Issue 1
First Page 11
Last Page 20
Subject Filiform papillae; Homozygotes; Paralogous
Subject MESH Embryonic and Fetal Development; Genes, Homeobox; Hair
Language eng
Bibliographic Citation Godwin AR, Capecchi MR. Hoxc13 mutant mice lack external hair. Genes Dev. 1998 Jan 1;12(1):11-20. Retrieved September 1,2006 from http://www.genesdev.org/cgi/content/full/12/1/11
Format Medium application/pdf
Identifier ir-main,368
ARK ark:/87278/s66d6bcv
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 704968
Reference URL https://collections.lib.utah.edu/ark:/87278/s66d6bcv
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