Hox11 paralogous genes are essential for metanephric kidney induction

Update item information
Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Wellik, Deneen M.; Hawkes, Patrick J.
Title Hox11 paralogous genes are essential for metanephric kidney induction
Date 2002-06-01
Description The mammalian Hox complex is divided into four linkage groups containing 13 sets of paralogous genes. These paralogous genes have retained functional redundancy during evolution. For this reason, loss of only one or two Hox genes within a paralogous group often results in incompletely penetrant phenotypes which are difficult to interpret by molecular analysis. For example, mice individually mutant for Hoxa11 or Hoxd11 show no discernible kidney abnormalities. Hoxa11/Hoxd11 double mutants, however, demonstrate hypoplasia of the kidneys. As described in this study, removal of the last Hox11 paralogous member, Hoxc11, results in the complete loss of metanephric kidney induction. In these triple mutants, the metanephric blastema condenses, and expression of early patterning genes, Pax2 and Wt1, is unperturbed. Eya1 expression is also intact. Six2 expression, however, is absent, as is expression of the inducing growth factor, Gdnf. In the absence of Gdnf, ureteric bud formation is not initiated. Molecular analysis of this phenotype demonstrates that Hox11 control of early metanephric induction is accomplished by the interaction of Hox11 genes with the pax-eya-six regulatory cascade, a pathway that may be used by Hox genes more generally for the induction of multiple structures along the anteroposterior axis.
Type Text
Publisher Cold Spring Harbor Lab Press
Journal Title Genes & Development
Volume 16
Issue 11
First Page 1423
Last Page 1432
DOI 10.1101/gad.993302
citatation_issn 8909369
Subject Metanephric; Six2; Wt1
Subject MESH DNA-Binding Proteins; Homeodomain Proteins; Kidney
Language eng
Bibliographic Citation Wellik, DM; Hawkes, PJ; Capecchi, MR. Hox11 paralogous genes are essential for metanephric kidney induction, Genes and Dev. 1999 Jun 15; 16, 1423-32. Retrieved July 7, 2006 from http://www.genesdev.org/cgi/content/full/16/11/1423.
Rights Management Copright 2002 Cold Spring Harbor Laboratory Press
Identifier ir-main,370
ARK ark:/87278/s6d22fzm
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 704566
Reference URL https://collections.lib.utah.edu/ark:/87278/s6d22fzm
Back to Search Results