Aberrant water homeostasis detected by stable isotope analysis

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Publication Type Journal Article
School or College College of Science
Department Biology
Creator Ehleringer, James R. ; Cerling, Thure E.
Other Author O'Grady, Shannon P.; Wende, Aadam R.; Remien, Christopher H.; Valenzuela, Luciano O.; Enright, Lindsey E.; Chesson, Lesley A.; Abel, E. Dale
Title Aberrant water homeostasis detected by stable isotope analysis
Date 2010-07-21
Description While isotopes are frequently used as tracers in investigations of disease physiology (i.e., 14C labeled glucose), few studies have examined the impact that disease, and disease-related alterations in metabolism, may have on stable isotope ratios at natural abundance levels. The isotopic composition of body water is heavily influenced by water metabolism and dietary patterns and may provide a platform for disease detection. By utilizing a model of streptozotocin (STZ)-induced diabetes as an index case of aberrant water homeostasis, we demonstrate that untreated diabetes mellitus results in distinct combinations, or signatures, of the hydrogen (d2H) and oxygen (d18O) isotope ratios in body water. Additionally, we show that the d2H and d18O values of body water are correlated with increased water flux, suggesting altered blood osmolality, due to hyperglycemia, as the mechanism behind this correlation. Further, we present a mathematical model describing the impact of water flux on the isotopic composition of body water and compare model predicted values with actual values. These data highlight the importance of factors such as water flux and energy expenditure on predictive models of body water and additionally provide a framework for using naturally occurring stable isotope ratios to monitor diseases that impact water homeostasis.
Type Text
Publisher Public Library of Science (PLoS)
Journal Title PLoS ONE
Volume 5
Issue 7
First Page e11699
Last Page 7
DOI 10.1371/journal.pone.0011699
citatation_issn 1932-6203
Language eng
Bibliographic Citation OGrady, S. P., Wende, A. R., Remien, C. H., Valenzuela, L. O., Enright, L. E., Chesson, L. A., Abel, E. D., Cerling, T. E., & Ehleringer, J. R. (2010). Aberrant water homeostasis detected by stable isotope analysis. PLoS ONE, 5(7), 1-7.
Rights Management (c) Ehleringer, J. R. (2010). Aberrant water homeostasis detected by stable isotope analysis. PLoS ONE, 5 (7), 1-7.
Format Medium application/pdf
Format Extent 348,131 bytes
Identifier ir-main,14773
ARK ark:/87278/s6bv80zt
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 704430
Reference URL https://collections.lib.utah.edu/ark:/87278/s6bv80zt