Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer

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Publication Type Manuscript
School or College College of Science
Department Biology
Creator Shapiro, Michael D.
Other Author Chan, Yingguang Frank; Marks, Melissa E.; Jones, Felicity C.; Villarreal Jr., Guadalupe; Brady, Shannon D.; Southwick, Audrey M.; Absher, Devin M.; Grimwood, Jane; Schmutz, Jeremy; Myers, Richard M.; Petrov, Dmitri; Jónsson, Bjarni; Schluter, Dolph; Bell, Michael A.; Kingsley, David M.
Title Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer
Date 2010-01-14
Description The molecular mechanisms underlying major phenotypic changes that have evolved repeatedly in nature are generally unknown. Pelvic loss in different natural populations of threespine stickleback fish has occurred by regulatory mutations deleting a tissue-specific enhancer of the Pituitary homeobox transcription factor 1 (Pitx1) gene. The high prevalence of deletion mutations at Pitx1 may be influenced by inherent structural features of the locus. Although Pitx1 null mutations are lethal in laboratory animals, Pitx1 regulatory mutations show molecular signatures of positive selection in pelvic-reduced populations. These studies illustrate how major expression and morphological changes can arise by single mutational leaps in natural populations, producing new adaptive alleles via recurrent regulatory alterations in a key developmental control gene.
Type Text
Publisher American Association for the Advancement of Science (AAAS)
Journal Title Science
Volume 327
Issue 5963
First Page 302
Last Page 305
DOI 10.1126/science.1182213
citatation_issn 0036-8075
Subject Adaptive evolution; Pelvic reduction; Pituitary homeobox transcription factor 1; Pitx1; Gasterosteus aculeatus
Subject LCSH Sticklebacks -- Evolution; Threespine stickleback -- Evolution
Language eng
Bibliographic Citation Chan, Y. F., Marks, M. E., Jones, F. C., Villarreal, G., Shapiro, M. D., Brady, S. D., Southwick, A. M., Absher, D. M., Grimwood, J., Schmutz, J., Myers, R. M., Petrov, D., Jónsson, B., Schluter, D., Bell, M. A., & Kingsley, D. M. (2010). Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer. Science, 327, 302-5.
Rights Management (c)American Association for the Advancement of Science (AAAS) http://dx.doi.org/10.1126/science.1182213
Format Medium application/pdf
Format Extent 894,818 bytes
Identifier ir-main,11962
ARK ark:/87278/s68d0dkq
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 704363
Reference URL https://collections.lib.utah.edu/ark:/87278/s68d0dkq
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