α-Conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes

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Publication Type Journal Article
School or College College of Science
Department Biology
Creator Olivera, Baldomero M.; McIntosh, J. Michael
Other Author Kulak, Jennifer M.; Nguyen, Thu A.
Title α-Conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes
Date 1997
Description Activation of presynaptic nicotinic acetylcholine receptors (nAChRs) can induce the release of neurotransmitters such as dopamine and norepinephrine in the CNS. Accumulating evidence suggests that distinct nAChR subtypes are involved; however, it has been difficult to determine the subunit composition of these receptors, in part because of the lack of a sufficient variety of selective nAChR ligands. We present experimental data that at least two different nAChR complexes are involved in dopamine release, one of which has an α3/β2 subunit interface.
Type Text
Publisher Society for Neuroscience
Journal Title Journal of Neuroscience
Volume 17
Issue 14
First Page 5263
Last Page 5270
Subject Conotoxins; a-Conotoxin MII
Subject LCSH Conus; Marine toxins; Synaptosomes; Presynaptic receptors; Dopamine -- Antagonists
Language eng
Bibliographic Citation Kulak, J. M., Nguyen, T. A., Olivera, B. M., & McIntosh, J. M. (1997). α-Conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes. Journal of Neuroscience, 17(14), 5263-70.
Rights Management (c) Society for Neuroscience http://www.jneurosci.org/
Format Medium application/pdf (portable document)
Format Extent 391,058 bytes
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