Comment on: Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

Update item information
Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Couldwell, William T.
Title Comment on: Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials
Date 1994
Description The long-term consequences of adenovirus-mediated conditional cytotoxic gene therapy for gliomas remain uncharacterized. We report here detection of active brain inflammation 3 months after successful inhibition of syngeneic glioma growth. The inflammatory infiltrate consisted of activated macrophages/microglia and astrocytes, and T lymphocytes positive for leucosyalin, CD3 and CD8, and included secondary demyelination. We detected strong widespread herpes simplex virus 1 thymidine kinase immunoreactivity and vector genomes throughout large areas of the brain. Thus, patient evaluation and the design of clinical trials in ongoing and future gene therapy for brain glioblastoma must address not only tumor-killing efficiency, but also long-term active brain inflammation, loss of myelin fibers and persistent transgene expression.
Type Text
Publisher American Association of Neurological Surgeons (AANS)
Volume 7
Issue 6
First Page 1
Last Page 2
Subject Brain inflammation; Herpes simplex virus-1; Thymidine kinase; Syngeneic glioma; Adenovirus-mediated gene therapy
Subject LCSH Gliomas -- Treatment; Gene therapy -- Adverse effects; Encephalitis
Language eng
Bibliographic Citation Couldwell, W. T. (1999). Comment on: Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials. Neurosurgical Focus, 7(6), 1-2.
Rights Management (c) American Association of Neurological Surgeons
Format Medium application/pdf
Format Extent 28,790 bytes
Identifier ir-main,12875
ARK ark:/87278/s6ms4b2k
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 704337
Reference URL https://collections.lib.utah.edu/ark:/87278/s6ms4b2k