Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Economides, Kyriakos D.; Zeltser, Lori
Title Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae
Date 2003-04-15
Description To address the expression and function of Hoxb13, the 5' most Hox gene in the HoxB cluster, we have generated mice with loss-of-function and beta-galactosidase reporter insertion alleles of this gene. Mice homozygous for Hoxb13 loss-of-function mutations show overgrowth in all major structures derived from the tail bud, including the developing secondary neural tube (SNT), the caudal spinal ganglia, and the caudal vertebrae. Using the beta-galactosidase reporter allele of Hoxb13, also a loss-of-function allele, we found that the expression patterns of Hoxb13 in the developing spinal cord and caudal mesoderm are closely associated with overgrowth phenotypes in the tails of homozygous mutant animals. These phenotypes can be explained by the observed increased cell proliferation and decreased levels of apoptosis within the tail of homozygous mutant mice. This analysis of Hoxb13 function suggests that this 5' Hox gene may act as an inhibitor of neuronal cell proliferation, an activator of apoptotic pathways in the SNT, and as a general repressor of growth in the caudal vertebrae. Copyright 2003 Elsevier Science (USA)
Type Text
Publisher Academic Press Ltd.
Volume 256
Issue 2
First Page 317
Last Page 330
Subject Animals; Axons; Ganglia, Spinal; Mice; Spinal Cord
Subject MESH Gene Expression Regulation, Developmental; Mutation; Spine; Tail
Language eng
Bibliographic Citation Dev Biol. 2003 Apr 15;256(2):317-30. Economides KD, Zeltser L, Capecchi MR. Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae.
Rights Management Copyright © 2003 Academic Press. All rights reserved.
Format Medium application/pdf
Identifier ir-main,581
ARK ark:/87278/s60c5d22
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 704282
Reference URL https://collections.lib.utah.edu/ark:/87278/s60c5d22
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