Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Chisaka, Osamu; Musci, Teresa S.
Title Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6.
Date 2002-06-27
Description Gene targeting in mouse embryo-derived stem cells has been used to generate mice with a disruption in the homeobox gene Hox-1.6. Mice heterozygous at the Hox-1.6 locus appear normal, whereas Hox-1.6-/Hox-1.6- mice die at or shortly after birth. These homozygotes exhibit profound defects in the formation of the external, middle and inner ears as well as in specific hindbrain nuclei, and in cranial nerves and ganglia. The affected tissues lie within a narrow region along the anteroposterior axis of the mouse but are of diverse embryonic origin. The set of defects associated with the disruption of Hox-1.6 is distinct from and nonoverlapping with that of the closely linked Hox-1.5 gene. But both mutations cause loss, rather than homeotic transformation, of tissues and structures
Type Text
Publisher Nature Publishing Group
Volume 355
Issue 6360
First Page 516
Last Page 520
Subject Chromosome Mapping; Genetic Vectors; Mice, Inbred C57BL
Subject MESH Cranial Nerves; Ear; Genes, Homeobox
Language eng
Bibliographic Citation Nature. 1992 Feb 6;355(6360):516-20. Chisaka O, Musci TS, Capecchi MR. Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6. Retrieved on November 1 2006 from http://www.nature.com/nature/journal/v355/n6360/abs/355516a0.html.
Rights Management copyright © 1992 Nature Publishing Group. All Rights Reserved.
Format Medium application/pdf
Identifier ir-main,521
ARK ark:/87278/s61g14hd
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 704066
Reference URL https://collections.lib.utah.edu/ark:/87278/s61g14hd
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