Performance Characteristics of the COBAS HCV TaqMan ASR Using Armored RNA Calibrators

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Publication Type Poster
School or College School of Medicine
Department Pathology
Program ARUP Institute for Clinical and Experimental Pathology
Creator Konnick, Eric Q.; Williams, Sheri M.; Ashwood, Edward R.; Hillyard, David R.
Title Performance Characteristics of the COBAS HCV TaqMan ASR Using Armored RNA Calibrators
Date 2003-04-22
Description As improved therapies have become available for Hepatititis C Virus (HCV) infection, the use of assays to quantitate HCV RNA has increased dramatically (3, 14, 16). The initial use of these assays was to predict the likelihood of therapy based on baseline HCV RNA levels. These reports indicated that HCV RNA levels >2,000,000 HCV RNA copies/mL were indicative of a decreased response to therapy. Other studies have suggested that the presence or absence of HCV RNA at a particular time point during therapy is predictive of relapse (5, 18). Recent data, including that from pegylated interferon treatment studies (2, 4, 6, 7, 17), have provided additional incentive for HCV RNA quantitative monitoring. This work suggests that quantitative HCV testing can be used to identify patients for whom HCV viral load does not decrease greater than 2 logs during the first 12 weeks of treatment. Such patients are found to have a high likelihood of treatment failure(1, 4, 12, 19).
Type Text
Publisher University of Utah
Subject Roche Amplicor Monitor; NGI Superquant; patients
Subject MESH Hepatitis C, Chronic; Therapeutics; RNA; Monitoring, Immunologic
Language eng
Bibliographic Citation Konnick EQ, Williams SM, Ashwood ER, Hillyard DR. Performance Characteristics of the COBAS HCV TaqMan ASR Using Armored RNA Calibrators.
Format Medium application/pdf
Identifier ir-main,500
ARK ark:/87278/s6pr8d7f
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 703940
Reference URL https://collections.lib.utah.edu/ark:/87278/s6pr8d7f
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