Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton.

Update item information
Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Wellik, Deneen M.
Title Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton.
Date 2003-07-18
Description Mice in which all members of the Hox10 or Hox11 paralogous group are disrupted provide evidence that these Hox genes are involved in global patterning of the axial and appendicular skeleton. In the absence of Hox10 function, no lumbar vertebrae are formed. Instead, ribs project from all posterior vertebrae, extending caudally from the last thoracic vertebrae to beyond the sacral region. In the absence of Hox11 function, sacral vertebrae are not formed and instead these vertebrae assume a lumbar identity. The redundancy among these paralogous family members is so great that this global aspect of Hox patterning is not apparent in mice that are mutant for five of the six paralogous alleles.
Type Text
Publisher American Association for the Advancement of Science (AAAS)
Volume 301
Issue 5631
First Page 363
Last Page 367
Subject Alleles; Animals; Forelimb; Gene Expression Regulation, Developmental; Hindlimb
Subject MESH Body Patterning; Genes, Homeobox; Oncogene Proteins; Spine
Language eng
Bibliographic Citation Science. 2003 Jul 18;301(5631):363-7. Wellik DM, Capecchi MR. Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Retrieved on November 1 2006 from http://www.sciencemag.org/cgi/content/full/301/5631/363.
Rights Management copyright © 2003 American Association for the Advancement of Science. All Rights Reserved.
Format Medium application/pdf
Identifier ir-main,534
ARK ark:/87278/s6zc8m5q
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 703907
Reference URL https://collections.lib.utah.edu/ark:/87278/s6zc8m5q
Back to Search Results