Xanthine oxidoreductase is central to the evolution and function of the innate immune system.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Vorbach, Claudia; Harrison, Roger
Title Xanthine oxidoreductase is central to the evolution and function of the innate immune system.
Date 2003-09-01
Description The housekeeping enzyme xanthine oxidoreductase (XOR) has been studied intensively over the past 100 years, yet the complexity of its in vivo function is still poorly understood. A large body of literature focuses on the different catalyltic forms of XOR and their importance in the synthesis of reactive oxygen and reactive nitrogen species, which are involved in many disease processes. More recently, various protective physiological roles of XOR have been recognized. We summarize for the first time that XOR is a component of the innate immune system. Because XOR is involved in multiple features of innate immunity we suggest that it is central to the evolution and function of this ancient defense system. We present evidence suggesting that XOR is a direct downstream target of the evolutionarily conserved Toll-like receptor-NF-kB pathway and discuss that numerous forms of post-translational modification of XOR could provide intrinsic molecular switches that make XOR an ideal component of various fast innate immune responses.
Type Text
Publisher Elsevier
Subject Animals; Gene Expression Regulation, Enzymologic; Humans; Immune System; Models, Biological
Subject MESH Evolution, Molecular; Immunity, Natural; Xanthine Dehydrogenase; Xanthine Oxidase
Language eng
Rights Management Trends Immunol. 2003 Sep;24(9):512-7. Vorbach C, Harrison R, Capecchi MR. Xanthine oxidoreductase is central to the evolution and function of the innate immune system. Retrieved on November 2, 2006 from http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W7H-4979FJN-1&_coverDate=09%2F30%2F2003&_alid=479973877&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6627&_sort=d&view=c&_acct=C000049956&_version=1&_urlVersion=0&_userid=990933&md5=3814fdfba4cb6fa0f39da140c5a1b4c9.
Format Medium application/pdf
Identifier ir-main,569
ARK ark:/87278/s6ht36m4
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 703805
Reference URL https://collections.lib.utah.edu/ark:/87278/s6ht36m4
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