Ultrasound-enhanced localized chemotherapy of drug-sensitive and multidrug resistant tumors

Update item information
Publication Type Journal Article
School or College College of Engineering
Department Bioengineering
Creator Christensen, Douglas A.
Other Author Rapoport, Natalya Y.; Gao, Zhonggao; Kamaev, Pavel
Title Ultrasound-enhanced localized chemotherapy of drug-sensitive and multidrug resistant tumors
Date 2006
Description A new modality of targeted tumor chemotherapy is based on the drug encapsulation in polymeric nanoparticles followed by a localized release at the tumor site triggered by focused ultrasound. Effect of 1 MHz and 3 MHz unfocused ultrasound applied locally to the tumor on the Doxorubicin (DOX) biodistribution and tumor growth rates was measured for ovarian carcinoma tumors in nu/nu mice. The bioeffects of ultrasound were investigated on the systemic and cellular levels. Growth rates of A2780 ovarian carcinoma tumors were substantially reduced by combining micellar drug delivery with tumor irradiation. Ultrasound effect was not thermal as manifested by intratumoral temperature measurements during sonication. Biodistribution studies showed that ultrasound did not enhance micelle extravasation. Main mechanisms of the ultrasound-enhanced chemotherapy included (i) passive targeting of drug-loaded micelles to the tumor interstitium; (ii) ultrasound-triggered localized drug release from micelles in the tumor volume; (iii) enhanced micelle and drug diffusion through the tumor interstitium; and (iv) ultrasound-triggered cell membrane damage resulting in the enhanced micelle and drug uptake by tumor cells.
Type Text
Publisher American Institute of Physics (AIP)
Volume 829
First Page 481
Last Page 485
DOI 10.1063/1.2205521
citatation_issn 0094243X
Subject Ultrasound-enhanced chemotherapy; Drug-resistant tumors; Biodistribution; Tumor sonication
Subject LCSH Chemotherapy; Ovaries -- Cancer -- Treatment; Colon (Anatomy) -- Cancer -- Treatment
Subject MESH Ultrasonography
Language eng
Conference Title THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound; 27-29 October 2005; Boston, Massachusetts (USA)
Bibliographic Citation Rapoport, N. Y., Gao, Z., Kamaev, P., & Christensen, D. A. (2006). Ultrasound-enhanced localized chemotherapy of drug-sensitive and multidrug resistant tumors. AIP Conference Proceedings, 829, 481-5.
Rights Management (c)American Institute of Physics. The following article appeared in Rapoport, N. Y., Gao, Z., Kamaev, P., & Christensen, D. A., AIP Conference Proceedings, 829, 2006 and may be found at http://dx.doi.org/10.1063/1.2205521
Format Medium application/pdf
Format Extent 262,958 bytes
Identifier ir-main,11648
ARK ark:/87278/s6v41cdz
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 703613
Reference URL https://collections.lib.utah.edu/ark:/87278/s6v41cdz