Moyamoya phenomenon after radiation for optic glioma

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Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Kestle, John R. W.
Other Author Hoffman, Harold J.; Mock, Antonio R.
Title Moyamoya phenomenon after radiation for optic glioma
Date 1993
Description The role of radiotherapy in the management of patients with optic pathway glioma is controversial. In a series of patients with optic pathway glioma treated at The Hospital for Sick Children in Toronto, five children were encountered who developed moyamoya phenomenon after radiotherapy. A retrospective review of the medical records was undertaken in order to assess the relationship between optic pathway glioma, neurofibromatosis type 1 (NF1), radiation therapy, and moyamoya disease. Forty-seven patients with optic pathway glioma were operated on at The Hospital for Sick Children between 1971 and 1990. The moyamoya phenomenon did not occur in any of the 19 patients not receiving radiotherapy. Among the 28 patients who received radiotherapy, five developed moyamoya disease (two of 23 without NF1 and three of five with NF1). There was a statistically significant relationship between radiotherapy and moyamoya disease when the analysis was stratified according to the presence of NF1 (Mantel-Haensel chisquared test 15.23, p<0.01). The high incidence of moyamoya disease (three of five cases, or 60%) in patients with NF1 who have undergone radiotherapy suggests a synergistic relationship that should be considered when formulating a treatment plan for NF1 patients with optic pathway glioma.
Type Text
Publisher American Association of Neurological Surgeons (AANS)
Volume 79
Issue 6
First Page 32
Last Page 36
Subject Optic pathway glioma
Subject LCSH Moyamoya disease; Radiotherapy -- Complications; Gliomas
Language eng
Bibliographic Citation Kestle, J. R. W., Hoffman, H. J., & Mock, A. R. (1993). Moyamoya phenomenon after radiation for optic glioma. Journal of Neurosurgery, 79(6), 32-6.
Rights Management (c) American Association of Neurological Surgeons
Format Medium application/pdf
Format Extent 681,363 bytes
Identifier ir-main,13129
ARK ark:/87278/s6rb7nsm
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 703433
Reference URL https://collections.lib.utah.edu/ark:/87278/s6rb7nsm
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