Origins and affinities of modern humans: a comparison of mitochondrial and nuclear genetic data

Update item information
Publication Type Journal Article
School or College School of Medicine; College of Social & Behavioral Science
Department Anthropology; Human Genetics
Creator Rogers, Alan R.; Jorde, Lynn B.
Other Author Bamshad, M. J.; Watkins, W. S.; Zenger, R.; Fraley, A. E.; Krakowiak, P. A.; Carpenter, K. D.; Soodyall, H.; Jenkins, T.
Title Origins and affinities of modern humans: a comparison of mitochondrial and nuclear genetic data
Date 1995
Description To test hypotheses about the origin of modern humans, we analyzed mtDNA sequences, 30 nuclear restriction-site polymorphisms (RSPs), and 30 tetranucleotide short tandem repeat (STR) polymorphisms in 243 Africans, Asians, and Europeans. An evolutionary tree based on mtDNA displays deep African branches, indicating greater genetic diversity for African populations. This finding, which is consistent with previous mtDNA analyses, has been interpreted as evidence for an African origin of modern humans. Both sets of nuclear polymorphisms, as well as a third set of trinucleotide polymorphisms, are highly consistent with one another but fail to show deep branches for African populations. These results, which represent the first direct comparison of mtDNA and nuclear genetic data in major continental populations, undermine the genetic evidence for an African origin of modern humans.
Type Text
Publisher University of Chicago Press
Volume 57
First Page 523
Last Page 538
Subject Base Sequence; Variation (Genetics); Base Sequence
Subject MESH Polymorphism, Genetic; Genetics, Population; DNA, Mitochondrial
Language eng
Bibliographic Citation Rogers, A. R., Jorde, L. B., Bamshad, M. J., Watkins, W. S., Zenger, R., Fraley, A. E., Krakowiak, P. A., Carpenter, K. D., Soodyall, H., & Jenkins, T. (1995). Origins and affinities of modern humans: a comparison of mitochondrial and nuclear genetic data. American Journal of Human Genetics, 57, 523-38.
Rights Management (c) University of Chicago Press
Format Medium application/pdf
Format Extent 2,391,595 bytes
Identifier ir-main,1850
ARK ark:/87278/s6sq9hk4
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2013-02-26
ID 703332
Reference URL https://collections.lib.utah.edu/ark:/87278/s6sq9hk4
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