Ascertainment bias for non-twin relatives in twin proband studies

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Publication Type Journal Article
School or College College of Social & Behavioral Science
Department Anthropology
Creator O'Rourke, Dennis H.
Other Author Rice, John; Gottesman, Irving I.; Suarez, Brian K.; Reich, Theodore
Title Ascertainment bias for non-twin relatives in twin proband studies
Date 1982
Description When families are ascertained through affected twins, as for example when twin probands are selected from a registry and their non-twin relatives studied, a correction for ascertainment bias is needed. It is shown that probandwise counting (where relatives of doubly ascertained twin pairs are counted twice) is the appropriate method. The bias resulting from pairwise counting is given and depends on the genetic model and on the probability of selecting an affected twin as a proband. For the multifactorial and generalized single major locus models the bias is small, and the problems associated with nonindependent ascertainment are negligible in practice.
Type Text
Publisher Karger (S. Karger AG)
First Page 202
Last Page 207
Subject Genetic; Transmission; Models
Language eng
Bibliographic Citation Rice, J., Gottesman, I. I., Suarez, B. K., O'Rourke, D. H., & Reich, T. (1982). Ascertainment bias for non-twin relatives in twin proband studies. Human Heredity, 32, 202-7.
Rights Management (c) Karger (S. Karger AG)
Format Medium application/pdf
Format Extent 922,781 bytes
Identifier ir-main,1310
ARK ark:/87278/s6qz2v6g
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 703317
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