Prognostic variables in surgery for skull base meningiomas

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Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Couldwell, William T.
Other Author Lefkowitz, Michael A.; Hinton, David R.; Weiss, Martin H.; Giannotta, Steven L.
Title Prognostic variables in surgery for skull base meningiomas
Date 1997
Description The authors have retrospectively analyzed selected surgical and pathological observations made among a group of 20 patients harboring recurrent cranial base meningiomas in an attempt to reveal which factors may be important in predicting tumor recurrence. This cohort was compared with a group of 34 patients with cranial base meningiomas that underwent primary resection and in whom tumor recurrence has not been demonstrated over a median follow-up period of 33 months. Features analyzed included brain, cranial nerve, carotid artery, or muscle invasion as well as tumor cellularity, nucleolar prominence, cellular pleomorphism, and percentage of cells staining positive for the Ki-67 antigen. As expected, increased cellularity and tumor necrosis were relatively more prevalent in recurrent tumors. With regard to tumor type, atypical and anaplastic tumors were more common in the group of patients with recurrent tumor compared with the primary group (p < 0.02). As expected, increased cellularity was relatively more prominent in recurrent tumors. Invasion of muscle and bone (72%) was more frequently associated with recurrent tumors, suggesting that these characteristics may be important features of recurrent skull base meningiomas.
Type Text
Publisher American Association of Neurological Surgeons (AANS)
Volume 2
Issue 4
Subject Skull base; Prognostic factor; Recurrence
Subject LCSH Meningioma -- Surgery; Meningioma -- Relapse; Brain -- Tumors -- Surgery
Subject MESH Neoplasms; Prognosis
Language eng
Bibliographic Citation Lefkowitz, M. A., Hinton, D. R., Weiss, M. H., Giannotta, S. L., & Couldwell, W. T. (1997). Prognostic variables in surgery for skull base meningiomas. Neurosurgical Focus, 2(4), e2.
Rights Management (c) American Association of Neurological Surgeons
Format Medium application/pdf
Format Extent 51,531 bytes
Identifier ir-main,12560
ARK ark:/87278/s61v5z6m
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 703215
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