Polypeptide chain termination in vitro: isolation of a release factor.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Title Polypeptide chain termination in vitro: isolation of a release factor.
Date 1967-09-01
Description The growing polypeptide chain remains bound to the ribosome-messenger RNA complex through the sRNA carrying the last amino acid incorporated into the polypeptide chain.' On completion of the polypeptide chain a mechanism must exist for releasing it from the protein-synthesizing machinery. To date, most of the effort has been concentrated on establishing the coded information required for this event.2-5 Very little is known about the biochemical mechanism of releasing the finished protein. The chain-terminating codon has to be read and the last peptidyl-sRNA bond must be cleaved. What components are required for this process remains to be determined.
Type Text
Publisher National Academy of Sciences of the United States of America.
Volume 58
Issue 3
First Page 1144
Last Page 1151
Subject Carbon Isotopes; Phenylalanine; Proteins
Subject MESH Genetic Code; Peptide Biosynthesis; Ribosomes
Language eng
Bibliographic Citation Proc Natl Acad Sci U S A. 1967 Sep;58(3):1144-51: Capecchi MR. Polypeptide chain termination in vitro: isolation of a release factor. Retrieved on September 22.2006 from http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=5233840.
Rights Management Copyright © 1967 National Academy of Sciences of the United States of America. All Rights Reserved.
Format Medium application/pdf
Identifier ir-main,455
ARK ark:/87278/s6h7100z
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 703166
Reference URL https://collections.lib.utah.edu/ark:/87278/s6h7100z
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