Encoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglion

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Publication Type Journal Article
School or College School of Medicine; College of Engineering
Department Ophthalmology; Bioengineering; Surgery; Physiology
Creator Normann, Richard A.; Shoham, Shy
Other Author Stein, Richard B.; Aoyagi, Yoichiro; Weber, David J.
Title Encoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglion
Date 2004
Description Recent advances in microelectrode array technology now permit a direct examination of the way populations of sensory neurons encode information about a limb's position in space. To address this issue, we recorded nerve impulses from about 100 single units simultaneously in the L6 and L7 dorsal root ganglia (DRG) of the anesthetized cat. Movement sensors, placed near the hip, knee, ankle, and foot, recorded passive movements of the cat's limb while it was moved pseudo-randomly. The firing rate of the neurons was correlated with the position of the limb in various coordinate systems. The firing rates were less correlated to the position of the foot in Cartesian coordinates (x, y) than in joint angular coordinates (hip, knee, ankle), or in polar coordinates. A model was developed in which position and its derivatives are encoded linearly, followed by a nonlinear spike-generating process. Adding the nonlinear portion significantly increased the correlations in all coordinate systems, and the full models were able to accurately predict the firing rates of various types of sensory neurons. The observed residual variability is captured by a simple stochastic model. Our results suggest that compact encoding models for primary afferents recorded at the DRG are well represented in polar coordinates, as has previously been suggested for the cortical and spinal representation of movement. This study illustrates how sensory receptors encode a sense of limb position, and it provides a general framework for modeling sensory encoding by populations of neurons.
Type Text
Publisher National Research Council Canada Research Press
Volume 82
Issue 09-Aug
First Page 757
Last Page 768
Subject Sensory; Encoding; Multielectrode; Dorsal Root Ganglion; Cutaneour; Muscle
Subject MESH Cats; Electrodes; Ganglia, Spinal; Neurons, Afferent
Language eng
Bibliographic Citation Stein RB, Aoyagi Y, Weber DJ, Shoham S, Normann RA. (2004). Encoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglion. Can J Physiol Pharmacol, 82(8-9), 757-68
Rights Management © National Research Council Canada Research Press
Format Medium application/pdf
Identifier ir-main,12756
ARK ark:/87278/s65t43nm
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 702976
Reference URL https://collections.lib.utah.edu/ark:/87278/s65t43nm
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