Analytical characteristics of ICAT-LC-MS/MS for quantitative proteomics studies

Update item information
Publication Type Abstract
School or College School of Medicine
Department Pathology
Program ARUP Institute for Clinical and Experimental Pathology
Creator Vaughn, Cecily P.; Crockett, David K.; Lim, Megan S.; Elenitoba-Johnson, Kojo S.J.
Title Analytical characteristics of ICAT-LC-MS/MS for quantitative proteomics studies
Date 2005-06-03
Description Recent studies have employed isotope-coded affinity tags (ICAT) in concert with tandem mass spectrometry (MS/MS) to assess differential expression of proteins on a proteomic scale and perform unbiased quantitative comparisons between samples from different physiological or disease states. We sought to determine the performance characteristics and analytical profile of ICAT-based quantitative proteomics studies using proteins released by follicular lymphoma (FL)-derived cells as a model system.
Type Text
Publisher University of Utah, Associated and Regional University Pathologists (ARUP) Institute for Clinical and Experimental Pathology
Subject isotope-coded affinity tags; ICAT; mass spectrometry; MS/MS; proteomic scale; FL
Subject MESH Isotope Labeling; Proteins; Proteomics; Lymphoma, Follicular; Peptides
Language eng
Rights Management http://creativecommons.org/licenses/by-nc-nd/2.5/
Format Medium application/pdf
Format Extent 37,720 bytes
Identifier ir-main,134
ARK ark:/87278/s6vt2975
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 702902
Reference URL https://collections.lib.utah.edu/ark:/87278/s6vt2975
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