Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women.

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Publication Type Journal Article
School or College School of Medicine
Department Pediatrics; Obstetrics & Gynecology
Creator Varner, Michael W.
Other Author Hendler, Israel; Schatz, Michael; Momirova, Valerija; Wise, Robert; Landon, Mark; Mabie, William; Newman, Roger B.; Kiley, James; Hauth, John C.; Moawad, Atef; Caritis, Steven N.; Spong, Catherine Y.; Leveno, Kenneth J.; Miodovnik, Menachem; Meis, Paul; Wapner Ronald J.; Paul, Richard H.; O'sullivan, Mary Jo; MJ, Thurnau, Gary R.; Conway, Deborah L.; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.
Title Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women.
Date 2006-07
Description OBJECTIVE: To evaluate whether maternal obesity is associated with pulmonary and nonpulmonary pregnancy complications in asthmatic women. METHODS: This is a secondary analysis of the prospective cohort Asthma During Pregnancy Study. Asthma patients were classified as having either mild or moderate to severe disease at the beginning of the study. Rates of pulmonary complications of asthma in asthmatic women and rates of nonpulmonary complications of pregnancy among asthma patients and controls, were compared between obese (body mass index > or = 30 kg/m2) and nonobese women. RESULTS: Maternal body mass index and pregnancy outcome data were available for 1,699 of 1,812 asthmatic women and for 867 of 881 controls. Of the asthma subjects, 30.7% (521) were obese compared with 25.5% of the controls, P = .006. Obese women, regardless of whether they had asthma, were more likely to undergo cesarean delivery (OR 1.6, 95% confidence interval [CI]1.3-2.0) to develop preeclampsia or gestational hypertension (OR 1.7 95% CI 1.3-2.3) and gestational diabetes (OR 4.2, 95% CI 2.8-6.3). There were no differences in the rates of overall asthma improvement (20.6% compared with 23.6%, P = .36) or deterioration (33.3% compared with 28.8%, P = .20) between obese and nonobese asthma patients. After adjustment for confounding variables, obesity, not asthma, was associated with nonpulmonary complications of pregnancy, and obesity was associated with an increase in asthma exacerbations as well (OR 1.3, 95% CI 1.1-1.7). CONCLUSION: Obesity is associated with an increased risk of asthma exacerbations during pregnancy. The increased rate of nonpulmonary complications of pregnancy in asthma patients is associated with obesity in this population and not with asthma status. LEVEL OF EVIDENCE: II-1.
Type Text
Publisher Lippincott, Williams & Wilkins
Volume 108
Issue 1
First Page 77
Last Page 82
Subject Asthma; Body Mass Index; Pregnancy Outcome; Lung Diseases
Subject MESH Asthma/*complications; Body Mass Index; Cesarean Section; Lung Diseases/*etiology
Language eng
Bibliographic Citation Hendler I, Schatz M, Momirova V, Wise R, Landon M, Mabie W, Newman RB, Kiley J, Hauth JC, Moawad A, Caritis SN, Spong CY, Leveno KJ, Miodovnik M, Meis P, Wapner RJ, Paul RH, Varner MW, O'sullivan MJ, Thurnau GR, Conway DL; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women. Obstet Gynecol. 2006 Jul;108(1):77-82. Retrieved on May 25th 2007 from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?orig_db=PubMed&db=PubMed&cmd=Search&term=Obstetrics+and+gynecology%5BJour%5D+AND+108%5Bvolume%5D+AND+1%5Bissue%5D+AND+77%5Bpage%5D+AND+Varner+M%5Bauthor%5D
Rights Management Copyright © Wolters Kluwer, Obstetrics and Gynecology, 108, 77-82, 2006
Format Medium application/pdf
Identifier ir-main,1593
ARK ark:/87278/s65x2t2z
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 702771
Reference URL https://collections.lib.utah.edu/ark:/87278/s65x2t2z
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