Hormonal changes throughout the menstrual cycle and increased anterior cruciate ligament laxity in females

Update item information
Publication Type Journal Article
School or College College of Health
Department Exercise & Sport Science
Creator Eisenman, Patricia A.
Other Author Heitz, Ned A.; Beck, Charles L.; Walker, James A.
Title Hormonal changes throughout the menstrual cycle and increased anterior cruciate ligament laxity in females
Date 1999-04
Description OBJECTIVE: To determine whether women experience significantly greater anterior cruciate ligament (ACL) laxity in conjunction with estrogen and progesterone surges during a normal 28- to 30-day menstrual cycle. DESIGN AND SETTING: Serial estrogen and progesterone levels were measured via radioimmunoassay procedures to identify the follicular and luteal phases of a subject's menstrual cycle and to determine periods of peak hormonal surges. Concomitant ACL laxity measures were taken using a knee arthrometer. Hormone levels and ACL laxity were assessed on days 1, 10, 11, 12, 13, 20, 21, 22, and 23 of the menstrual cycle. Day 1 corresponds to the menstrual phase, when estrogen and progesterone levels are at their lowest. Days 10 through 13 correspond to peak estrogen surge (follicular phase), and days 20 through 23 correspond to peak progesterone surge (luteal phase). SUBJECTS: Seven active females between the ages of 21 and 32 years with at least one apparently healthy knee (no known knee anomalies) volunteered for participation in this study. Each subject stated that she experienced a normal (28- to 30-day) menstrual cycle and was not currently taking any type of hormone therapy (eg, birth control medication). MEASUREMENTS: Blood was drawn on days 1, 10, 11, 12, 13, 20, 21, 22, and 23 of each subject's menstrual cycle, and ACL laxity measurements were assessed immediately after the blood draws. Estrogen and progesterone levels were determined via radioimmunoassay procedures, and ACL laxity was determined using a knee arthrometer. RESULTS: A within-subjects, repeated-measures analysis of variance was applied to determine the presence or absence of significant differences in ACL laxity values over the course of a subject's menstrual cycle. We found a significant difference in ACL laxity when comparing baseline levels of estrogen with peak levels of estrogen. A significant increase in ACL laxity was also noted when comparing baseline levels of progesterone with peak levels of progesterone. CONCLUSIONS: ACL laxity increased significantly throughout the menstrual cycle when comparing baseline with peak levels of estrogen and progesterone.
Type Text
Publisher National Athletic Trainers' Association
Volume 34
Issue 2
First Page 144
Last Page 149
Subject Estrogen; Progesterone; Knee Arthrometer; Radioimmunoassay
Subject MESH Estrogens; Menstrual Cycle; Anterior Cruciate Ligament
Language eng
Bibliographic Citation Heitz NA, Eisenman PA, Beck CL, Walker JA. Hormonal Changes Throughout the Menstrual Cycle and Increased Anterior Cruciate Ligament Laxity in Females. J Athl Train. 1999 Apr;34(2):144-149. Retrieved October 4, 2006 from http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16558557
Rights Management Copyright © National Athletic Trainers' Association, Journal of Athletic Training, 34(2), 144-149, 1999
Format Medium application/pdf
Format Extent 1.05 MB (1,106,097 Bytes)
Identifier ir-main,479
ARK ark:/87278/s6kw6058
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 702614
Reference URL https://collections.lib.utah.edu/ark:/87278/s6kw6058