Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Chisaka, Osamu
Title Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5.
Date 1991-04-11
Description Gene targeting in mouse embryo-derived stem cells has been used to disrupt the homeobox gene hox-1.5. Mice heterozygous at the hox-1.5 locus appear normal, whereas hox-1.5-/hox-1.5- mice die at or shortly after birth. These homozygotes are athymic, aparathyroid, have reduced thyroid and submaxillary tissue and exhibit a wide range of throat abnormalities. In addition, they often feature defects of the heart and arteries as well as craniofacial abnormalities. These deficiencies are remarkably similar to the pathology of the human congenital disorder DiGeorge's syndrome.
Type Text
Publisher Nature Publishing Group
Volume 350
Issue 6318
First Page 473
Last Page 479
Subject Abnormalities, Multiple; Animals, Newborn; Arteries; Bone and Bones; Cartilage; Esophagus; Gene Expression; Heart Defects, Congenital; Organ Specificity; Parathyroid Glands; Pharynx; Thymus Gland; Thyroid Gland; Trachea
Subject MESH Embryonic and Fetal Development; Genes, Homeobox; Restriction Mapping
Language eng
Bibliographic Citation Nature. 1991 Apr 11;350(6318):473-9. Chisaka O, Capecchi MR. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Retrieved on November 2, 2006 from http://www.nature.com/nature/journal/v350/n6318/abs/350473a0.html.
Rights Management copyright © 1991 Nature Publishing Group. All Rights Reserved.
Format Medium application/pdf
Identifier ir-main,564
ARK ark:/87278/s68k7t64
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 702601
Reference URL https://collections.lib.utah.edu/ark:/87278/s68k7t64
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