Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Condie, Brian G.; Bain, Gerard; Gottlieb, David I.
Title Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.
Date 1997-10-14
Description The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA receptor subunit develop a cleft secondary palate. GABA, the ligand for this receptor, is synthesized by the enzyme glutamic acid decarboxylase. We have disrupted one of the two mouse Gad genes by gene targeting and also find defects in the formation of the palate. The striking similarity in phenotype between the receptor and ligand mutations clearly demonstrates a role for GABA signaling in normal palate development.
Type Text
Publisher National Academy of Sciences of the United States of America.
Volume 94
Issue 21
First Page 11451
Last Page 11455
Subject Animals, Newborn; Crosses, Genetic
Subject MESH Cleft Palate; Glutamate Decarboxylase; Mice, Knockout; gamma-Aminobutyric Acid
Language eng
Bibliographic Citation Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11451-5: Condie BG, Bain G, Gottlieb DI, Capecchi MR. Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Retrieved on September 15.2006 from http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9326630
Rights Management Copyright 1966 National Academy of Sciences of the United States of America. All right Reserved
Format Medium application/pdf
Identifier ir-main,417
ARK ark:/87278/s6qc0mkw
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 702468
Reference URL https://collections.lib.utah.edu/ark:/87278/s6qc0mkw
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