| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Capecchi, Mario R. |
| Other Author |
Shen, Xiao Z.; Li, Ping; Weiss, Daiana; Fuchs, Sebastien; Xiao, Hong D.; Adams, Jon A.; Williams, Ifor R.; Taylor, W. Robert; Bernstein, Kenneth E. |
| Title |
Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma |
| Date |
2007 |
| Description |
Angiotensin-converting enzyne (ACE) is a pepitdase responsible for the cleavage of angiotensin I and Several other peptides. Here, gene targeting was used to switch control of the ACE locus from the endogenous promoter to the macrophage-specific c-fms promoter. Challenge of these mice, called ACE 10/10, with the aggressive mouse melanoma cell line B16 showed that they are remarkably resistant to tumor growth. |
| Type |
Text |
| Publisher |
American Society for Investigative Pathology |
| Volume |
170 |
| Issue |
6 |
| First Page |
2122 |
| Last Page |
2134 |
| Subject |
Macrophage enzyme; Melanoma resistance; Enhanced macrophage angiotensin-converting enzyme |
| Subject LCSH |
Angiotensin converting enzyme; Melanoma; Mice -- Genetics |
| Dissertation Institution |
University of Utah |
| Language |
eng |
| Bibliographic Citation |
Shen, X. Z., Li, P., Weiss, D., Fuchs, S., Xiao, H. D., Adams, J. A., Williams, I. R., Capecchi, M. R., Taylor, W. R., & Bernstein, K. E. (2007). Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. American Journal of Pathology, 170(6), 2122-34. June. |
| Rights Management |
©American Society for Investigative Pathology. Reproduced from Am J Pathol 2007, 170:2122-2134 with permission from the American Society for Investigative Pathology. http://ajp.amjpathol.org/cgi/content/abstract/165/3/1019 |
| Format Medium |
application/pdf |
| Format Extent |
1,760,622 bytes |
| Identifier |
ir-main,9160 |
| ARK |
ark:/87278/s66t14q3 |
| Setname |
ir_uspace |
| ID |
702382 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s66t14q3 |
