Quercetin: a treatment for hypertension? - a review of efficacy and mechanisms

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Publication Type Journal Article
School or College College of Health
Department Nutrition
Creator Jalili, Thunder
Other Author Larson, Abigail J.; Symons, J. David
Title Quercetin: a treatment for hypertension? - a review of efficacy and mechanisms
Date 2010
Description Quercetin is a polyphenolic flavonoid. Common sources in the diet are apples, onions, berries, and red wine. Epidemiological studies have found an inverse relationship between dietary quercetin intake and cardiovascular disease. This has led to in vitro, in vivo, and clinical research to determine the mechanism by which quercetin exerts cardioprotective effects. Recent studies have found a reduction in blood pressure when hypertensive (>140 mm Hg systolic and >90 mm Hg diastolic) animals and humans are supplemented with quercetin. Proposed mechanisms for the antihypertensive effect of quercetin include decreased oxidative stress, inhibition of angiotensin converting enzyme activity, improved endothelial function, direct action on the vascular smooth muscle, and/or modulation in cell signaling and gene expression. Although in vitro and in vivo evidence exists to support and refute each possibility, it is likely that quercetin influences multiple targets via a combination of known and as yet undiscovered mechanisms. The purpose of this review is to examine the mechanisms whereby quercetin might reduce blood pressure in hypertensive individuals.
Type Text
Publisher MDPI
Volume 3
First Page 237
Last Page 250
DOI 10.3390/ph3010237
Language eng
Bibliographic Citation Larson, A. J., Symons, J. D., & Jalili, T. (2010). Quercetin: a treatment for hypertension? - a review of efficacy and mechanisms. Pharmaceuticals, 3, 237-50.
Rights Management ©MDPI. 2010; Reprinted from Larson, A. J., Symons, J. D., & Jalili, T. (2010). Quercetin: a treatment for hypertension, a review of efficacy and mechanisms. Pharmaceuticals, 3, 237-50. doi:10.3390/ph3010237
Format Medium application/pdf
Format Extent 130,728 bytes
Identifier ir-main,16687
ARK ark:/87278/s6gx4vm3
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2013-03-07
ID 702258
Reference URL https://collections.lib.utah.edu/ark:/87278/s6gx4vm3
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