Pathophysiology of Idiopathic Intracranial Hypertension (IIH)

Identifier Pathophysiology_of_Idiopathic_Intracranial_Hypertension_IIH
Title Pathophysiology of Idiopathic Intracranial Hypertension (IIH)
Creator Padmaja Sudhakar; Sulakshna Aggarwal
Affiliation (PS) University of Kentucky, neurology and ophthalmology/neuro-ophthalmology, KY; (SA) Maulana Azad Medical College; India, New Delhi
Subject Centripetal Adiposity; Choroid Plexus; Idiopathic Intracranial Hypertension; Increased Central Venous Pressure; Leptin
Description This power point describes the pathophysiological mechanisms described in idiopathic intracranial hypertension(IIH). The authors have tried to elaborate the theories behind the development of IIH.
Date 2026-01
References 1.Idiopathic intracranial hypertension (pseudotumor cerebri): Epidemiology and pathogenesis - UpToDate [Internet]. [cited 2025 Nov 2]. Available from: https://www.uptodate.com/contents/idiopathic-intracranial-hypertension-pseudotumor-cerebri-epidemiology-and-pathogenesis?search=Idiopathic%20intracranial%20hypertension%20%3A%20epidemiology%20and%20pathogensis&source=search_result&selectedTitle=1~92&usage_type=default&display_rank=1. 2.BROWN PD, DAVIES SL, SPEAKE T, MILLAR ID. Molecular Mechanisms of Cerebrospinal Fluid Production. Neuroscience. 2004;129(4):957-70. 3.Colman BD, Boonstra F, Nguyen MN, Raviskanthan S, Sumithran P, White O, et al. Understanding the pathophysiology of idiopathic intracranial hypertension (IIH): a review of recent developments. J Neurol Neurosurg Psychiatry. 2024 Mar 13;95(4):375-83. 4.Brinker T, Stopa E, Morrison J, Klinge P. A new look at cerebrospinal fluid circulation. Fluids Barriers CNS. 2014 May 1;11:10. 5.Ball AK, Sinclair AJ, Curnow SJ, Tomlinson JW, Burdon MA, Walker EA, et al. Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance? Clin Endocrinol (Oxf). 2009 Jun;70(6):863-9. 6.Edwards LJ, Sharrack B, Ismail A, Tench CR, Gran B, Dhungana S, et al. Increased levels of interleukins 2 and 17 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension. Am J Clin Exp Immunol. 2013;2(3):234-44. 7.Altıokka-Uzun G, Tüzün E, Ekizoğlu E, Ulusoy C, Yentür S, Kürtüncü M, et al. Oligoclonal bands and increased cytokine levels in idiopathic intracranial hypertension. Cephalalgia Int J Headache. 2015 Nov;35(13):1153-61. 8.El-Tamawy MS, Zaki MA, Rashed LA, Esmail EH, Mohamed SS, Osama W. Oligoclonal bands and levels of interleukin 4, interleukin 10, and tumor necrosis factor alpha in idiopathic intracranial hypertension Egyptian patients. Egypt J Neurol Psychiatry Neurosurg. 2019 Dec 19;55(1):88. 9.Westgate CSJ, Botfield HF, Alimajstorovic Z, Yiangou A, Walsh M, Smith G, et al. Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension. JCI Insight [Internet]. 2021 May 24 [cited 2025 Nov 23];6(10). Available from: https://insight.jci.org/articles/view/145346. 10.Grech O, Seneviratne SY, Alimajstorovic Z, Yiangou A, Mitchell JL, Smith TB, et al. Nuclear Magnetic Resonance Spectroscopy Metabolomics in Idiopathic Intracranial Hypertension to Identify Markers of Disease and Headache. Neurology. 2022 Oct 18;99(16):e1702-14. 11.O'Reilly MW, Westgate CSJ, Hornby C, Botfield H, Taylor AE, Markey K, et al. A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics. JCI Insight [Internet]. 2019 Mar 21 [cited 2025 Nov 25];4(6). Available from: https://insight.jci.org/articles/view/125348. 12.Fraser JA, Bruce BB, Rucker J, Fraser LA, Atkins EJ, Newman NJ, et al. Risk factors for idiopathic intracranial hypertension in men: a case-control study. J Neurol Sci. 2010 Mar 15;290(1-2):86-9. 13.Sinclair AJ, Burdon MA, Nightingale PG, Ball AK, Good P, Matthews TD, et al. Low energy diet and intracranial pressure in women with idiopathic intracranial hypertension: prospective cohort study. The BMJ. 2010 Jul 7;341:c2701. 14.Westgate CSJ, Markey K, Mitchell JL, Yiangou A, Singhal R, Stewart P, et al. Increased systemic and adipose 11β-HSD1 activity in idiopathic intracranial hypertension. Eur J Endocrinol. 2022 May 18;187(2):323-33. 15.Cagnazzo F, Villain M, van Dokkum LE, Radu RA, Morganti R, Gascou G, et al. Concordance between venous sinus pressure and intracranial pressure in patients investigated for idiopathic intracranial hypertension. J Headache Pain. 2024 Sep 17;25(1):153. 16.Cardona-Collazos S, Arias A, Torres-Figueroa S, Meneses CA, Varon CA. Case report: Central venous stenosis-induced intracranial hypertension. Neurocir Engl Ed. 2025 Jul 1;36(4):500652.
Language eng
Format application/pdf
Format Creation Microsoft PowerPoint
Type Text
Collection Neuro-Ophthalmology Virtual Education Library: NOVEL https://NOVEL.utah.edu
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2026. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6ym7wz4
Setname ehsl_novel_novel
ID 2933018
Reference URL https://collections.lib.utah.edu/ark:/87278/s6ym7wz4