| Description |
Premature infants requiring mechanical ventilation are at high risk for developing necrotizing enterocolitis (NEC), a serious intestinal disease characterized by inflammation and tissue necrosis. AVR-48 is an anti-inflammatory compound that may improve outcomes in preterm infants by modulating inflammatory pathways. This study explored whether AVR-48 influences intestinal vascularization and growth in preterm lambs. Lambs were delivered at 128 days of gestation and treated with AVR-48 or a vehicle control for 6-7 days while on mechanical ventilation. After the study period, distal ileum samples were collected and examined for structural changes and capillary density using immunohistochemical analysis. Lambs managed with AVR-48 exhibited no statistically significant differences in capillary surface density of intestinal structure compared to control groups. While some measurements, such as villus length and crypt width, showed mild increases in the AVR-48 treated group, these changes did not reach statistical significance. Overall AVR-48 did not appear to adversely impact intestinal development. |
