Journal of Neuro-Ophthalmology, March 2013, Volume 33, Issue 1

Retinal Nerve Fiber Layer Thickness Using Spectral-Domain Optical Coherence Tomography in Patients With No Light Perception Secondary to Optic Atrophy

Optical coherence tomography (OCT) provides useful structural information that can augment functional data. Newer spectral-domain technology provides faster and higher resolution images than time-domain machines. Although each measures the same structures, the values systematically differ. We evaluated eyes with longstanding no light perception (NLP) visual acuity secondary to optic atrophy using spectral-domain OCT to determine minimum retinal nerve fiber layer (RNFL) thickness. The authors conducted a retrospective, crosssectional chart review study to identify patients with NLP acuity for 8 months or more and having a good quality Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) to measure the RNFL thickness. An unpaired t test compared the eyes with a previously published data set measured with time-domain OCT. Eleven eyes from 10 patients were examined with the Spectralis OCT. The mean duration of documented NLP acuity was 3.72 - 1.20 years. The mean RNFL thickness was 34.18 - 2.66 mm (95% co idence interval, 28.26- 40.11 mm). Mean RNFL thickness was significantly thinner on this spectral-domain OCT than previously published values on time-domain OCT (34.18 vs 45.42 mm, P = 0.004). Using the Spectralis OCT, mean RNFL thickness for NLP eyes due to optic atrophy is 28-40 mm. This provides clinicians useful information when considering how aggressively to manage patients with optic nerve disease.