| Title |
Novel Treatment for Radiation Optic Neuropathy With Intravenous Bevacizumab |
| Creator |
Farooq, Osman; Lincoff, Norah S; Saikali, Nicolas; Prasad, Dheerendra; Miletich, Robert S; Mechtler, Laszlo L |
| Affiliation |
School of Medicine (OF, NSL, NS, DP, RSM, LLM), Departments of Neurology (OF, NSL, NS, LLM), Ophthalmology (NSL), Radiation Medicine (DP), and Nuclear Medicine (RSM), University of Buffalo, Buffalo, New York Jacobs Neurologic Institute (OF, NSL), Buffalo, New York Women and Children's Hospital of Buffalo (OF), Buffalo, New York Ross Eye Institute (NSL), Buffalo, New York Dent Neurologic Institute (NS, RSM, LLM), Buffalo, New York Roswell Park Cancer Institute (DP, LLM), Buffalo, New York |
| Abstract |
Radiation optic neuropathy is a devastating form of vision loss that can occur months to years after radiation therapy for tumors and other lesions located in close proximity to the visual pathways. We present the case of a 24-year-old woman who underwent external beam radiation for treatment of a tectal pilocytic astrocytoma, and 5 years later she developed bilateral radiation optic neuropathy and radiation necrosis of the right temporal lobe. We opted to treat her with intravenous bevacizumab with 3 doses every 3 weeks, as well as dexamethasone and pentoxifylline. After the first infusion of bevacizumab, the patient noted improvement in vision and color vision, and a follow-up magnetic resonance imaging study showed that the previous enhancement of the optic nerves and chiasm was diminishing. Her vision improved dramatically and has remained stable over a 3-year period. |
| Subject |
Administration, Intravenous; Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Astrocytoma; Blindness; Brain Neoplasms; Electromagnetic Radiation; Female; Humans; Magnetic Resonance Imaging; Optic Nerve Diseases; Radiation Injuries |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
227348 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6x383kt/227348 |
