| Title |
Downbeat nystagmus. A case report of herpetic brain stem encephalitis. |
| Creator |
Hirst, L.W.; Clark, A.W.; Wolinsky, J.S.; Zee, D.S.; Kaizer, H.; Miller, N.R.; Tutschka, P.J.; Santos, G.W. |
| Abstract |
A 35-year-old man with aplastic anemia developed prominent downbeat nystagmus 80 days after receiving an allogeneic bone marrow transplant. A diagnosis of herpes simplex encephalitis was made which was confirmed by positive virus cultures at autopsy 1 week later. Routine pathologic examination of the brain stem revealed no lesions which would explain the downbeat nystagmus. Immunoperoxidase studies, however, revealed virus-infected neurones throughout the brain stem including the nuclei of the basis pontis, the superior olive, and nuclei of the spinal tracts of 5 and 10. The significance of ""negative"" pathologic brain stem findings in cases of downbeat nystagmus is discussed. |
| Subject |
Adult; Bone Marrow Transplantation; Brain Stern; Encephalitis; Herpes Simplex; Humans; Male; Nystagmus, Pathologic; Postoperative Complications |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
226841 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6157p5q/226841 |
