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Corneal permeability in patients with tonic pupil. A reevaluation of its cholinergic supersensitivity.

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Title Journal of Neuro-Ophthalmology, March 1990, Volume 10, Issue 1
Date 1990-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s61c530r
Setname ehsl_novel_jno
ID 226167
Reference URL https://collections.lib.utah.edu/ark:/87278/s61c530r

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Title Corneal permeability in patients with tonic pupil. A reevaluation of its cholinergic supersensitivity.
Creator Utsumi, Takashi.
Affiliation Department of Ophthalmology, Osaka Medical College, Japan.
Abstract Cholinergic supersensitivity of the iris sphincter helps to make the diagnosis of "tonic pupil." Because uncertain responses sometimes occur with mecholyl 2.5%, dilute solutions of pilocarpine are often used. There has always been some question as to whether individual variation in corneal permeability was one of the factors contributing to the variability in pupillary constriction to topical cholinergics in these patients. In this study, the degree of intraocular penetration of topical fluorescein was compared with the degree of pilocarpine-induced miosis in six tonic pupils and in seven age-matched normal controls. A noncontact fluorophotometer and a computerized videopupillogram were used. The patients showed a significant cholinergic supersensitivity in their affected tonic pupils and had normal intraocular penetration of fluorescein through the cornea in both eyes. It is concluded that the cholinergic supersensitivity of the iris in tonic pupils is not the result of increased corneal permeability but instead results from an increased sensitivity of the cholinergic receptors in iris sphincter muscles.
Subject Adult; Anterior Chamber; Cornea; Female; Fluorescein; Fluorsceins; Fluorophotometry; Humans; Male; Middle Older people; Miosis; Permeability; Pilocarpine; Tonic Pupil
OCR Text Show
Format application/pdf
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Setname ehsl_novel_jno
ID 226153
Reference URL https://collections.lib.utah.edu/ark:/87278/s61c530r/226153