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Show 216 LITERATURE ABSTRACTS sinus tumor when operated for the mucocele. In most, tumor was not suspected based on preoperative radiographs and computerized tomography. A brief discussion by Dr. Linberg following the article underlines the ophthalmologist's role in managing such patients. Lyn A. Sedwick, M. D. Clinical Doxorubicin Chemomyectomy: An Experimental Treatment for Benign Essential Blepharospasm and Hemifacial Spasm. Wirtschafter JD. Ophthalmology 1991; 98: 357- 66 ( Mar). [ Reprint requests to Dr. J. D. Wirtschafter, Department of Ophthalmology, University of Minnesota Medical School, 516 Delaware Street, S. E., Box 493, Minneapolis, MN 55455.] Twenty patients with either benign essential blepharospasm or hemifacial spasm were treated with local injections of doxorubicin in an attempt to achieve a more long- lasting chemodenervation or chemomyectomy than that of botulism injection. Although this appears to be a promising agent in the treatment of these distressing disorders, it seems that more patients, practice, and time is needed to maximize dose efficacy and placement and to minimize the rather serious local side effects. Lyn A. Sedwick, M. D. Herpes Reactivation and Ophthalmoplegia From Pituitary Adenoma Invading the Cavernous Sinus. Horton Je, Wilson CB, Hoyt WF. Arch OphthaImol 1991; 109: 323- 4 ( Mar). [ No reprint information given.] . An ~ 2- year- oldman with apparent herpes zoster I~ volvmg Vj and V2 and ophthalmoplegia same sld~ had computerized tomographic scanning which demonstrated a hemorrhagic pituitary adenoma. The authors speculate that pituitary apoplexy c. aused herpes reactivation and ophthalmoplegia by mass effect on cranial nerves III, IV, Vj , V2, and VI. Perhaps all of these patients deserve a scan early on. Lyn A. Sedwick, M. D. Orbital Decompression in Graves' Disease: The Predictability of Reduction of Proptosis. Wilson WB, Manke WF. Arch Ophthalmol 1991; 109: 343- 5 ( Mar). [ Reprint requests to Dr. W. B. Wilson, 850 E. Harvard ( 535), Denver, CO 80210.] The authors studied 42 orbits of 23 patients with Graves' disease who underwent inferior and medial wall decompression. By their analysis, they concluded that other factors than increase in orbital volume must be at work to affect the postoperative reduction in proptosis, including " orbital stiffness," because 9 orbits did not have the expected reduction in proptosis based on orbital volume measurement alone. Lyn A. Sedwick, M. D. Histologic Features of Human Orbicularis Oculi Treated With Botulinum A Toxin. Harris CP, Alderson K, Nebeker J, Holds JB, Anderson RL. Arch OphtJznlmoI1991; 109: 393- 5 ( Mar). [ Reprint requests to Dr. K. Alderson, Department of Neurology, University of Utah Medical Center, 50 N. Medical Drive, Salt Lake City, UT 84132.] Botulinum- Induced Changes in Monkey Eyelid Muscle: Comparison With Changes Seen in Extraocular Muscle. Porter JD, Strebeck S, Capra NF. Arch Ophthalmol 1991; 109: 396- 404 ( Mar). [ Reprint requests to Dr. J. D. Porter, Department of Anatomy. and Neurobiology, University of Kentucky MedICal Center, 800 Rose Street, Lexington, KY 40536- 0084.] T~ ese two articles study histologic sections of eyelIds treated with botulinum- in the first article from. patien. ts, and in the second from monkeys. In t~ e ~ u: st arhc~ e, regular light microscopy found no slgmficant difference between orbicularis muscle tr: ated with botulinum or not treated in patients With blepharospasm. In contrast, the second article presents data from monkey eyelids showing at~ ophy of all muscle fibers by light and electron ~ c~ oscopy. It is hard to reconcile these disparate fmdmgs by any obvious difference in methodology, e. g., time after injection to tissue sampling, etc. Lyn A. Sedwick, M. D. |
