Increased Endothelin-1 Plasma Levels in Patients with Multiple Sclerosis

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Title Journal of Neuro-Ophthalmology, March 2001, Volume 21, Issue 1
Date 2001-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6768mdm
Setname ehsl_novel_jno
ID 225148
Reference URL https://collections.lib.utah.edu/ark:/87278/s6768mdm

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Title Increased Endothelin-1 Plasma Levels in Patients with Multiple Sclerosis
Creator Haufschild, T; Shaw, SG; Kesselring, J; Flammer, J
Affiliation University Eye Clinic, Basel, Switzerland.
Abstract OBJECTIVE: We tested the hypothesis that the plasma level of endothelin-1 (ET-1) is increased in patients with multiple sclerosis (MS). The peptide ET-1 is one of the most potent known vasoconstrictors. An increased level of endothelin could explain some of the vascular symptoms of these patients. MATERIALS AND METHODS: A specific radioimmunoassay was used to determine ET-1 plasma levels. Twenty patients with MS were compared to 20 age- and sex-pair-matched healthy subjects. RESULTS: The plasma ET-1 levels were, on average, 224% higher in the patients with MS than in the controls (p < 0.005). The mean ET-1 levels (mean +/- standard deviation [SD]) were 3.5 +/- 0.83 pg/mL (min 2.13, max 5.37 pg/mL) in patients with MS and 1.56 +/- 0.3 pg/mL (min 0.9, max 2.13 pg/mL) in healthy volunteers. Neither the different forms nor stages of MS had an influence on the results. The ET-1 level was also not correlated with the duration of the disease. CONCLUSIONS: The plasma ET-1 level is markedly and significantly increased in patients with MS. Neither the cause of such an increase nor the pathogenetic role is known.
Subject Adult; Older people; Endothelin-1/blood; Female; Humans; Male; Middle Older people; Multiple Sclerosis/blood; Radioimmunoassay
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Format application/pdf
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Setname ehsl_novel_jno
ID 225141
Reference URL https://collections.lib.utah.edu/ark:/87278/s6768mdm/225141