| Title |
The Eyes of Mito-Mouse |
| Creator |
Biousse, V; Pardue, MT; Wallace, DC; Newman, NJ |
| Affiliation |
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA. vbiouss@emory.edu |
| Abstract |
The recent creation of several mouse models of mitochondrial diseases has provided new insights into the understanding of human mitochondrial disorders. Whether these animals have clinical or histologic ophthalmologic abnormalities is of great interest given the high frequency of such abnormalities in humans with mitochondrial disorders. In this article, we describe the currently available mouse models for mitochondrial diseases with special emphasis on their ocular phenotype. These mouse models demonstrate multiple and varied ophthalmologic manifestations. |
| Subject |
Animals; Chimera; Chloramphenicol/pharmacology; DNA-Binding Proteins; Disease Models, Animal; Drug Resistance/genetics; Eye Diseases/genetics; High Mobility Group Proteins; Mice; Mice, Knockout; Mitochondrial Diseases/genetics; Mitochondrial Proteins; Mutation; Nuclear Proteins/deficiency; Nuclear Proteins/genetics; Protein Synthesis Inhibitors/pharmacology; Repressor Proteins/genetics; Superoxide Dismutase/genetics; Transcription Factors/deficiency; Transcription Factors/genetics; Viral Proteins/genetics |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
225107 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6gr03vw/225107 |
