The Effect of Endrophonium Chloride on Muscle Balance in Normal Subjects and Those with Nonmyasthenic Strabismus

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Title Journal of Neuro-Ophthalmology, March 1997, Volume 17, Issue 1
Date 1997-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6jm5gqs
Setname ehsl_novel_jno
ID 224805
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jm5gqs

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Title The Effect of Endrophonium Chloride on Muscle Balance in Normal Subjects and Those with Nonmyasthenic Strabismus
Creator Siatkowski, RM; Shah, L; Feuer, WJ
Affiliation Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida, USA.
Abstract Because the Lancaster red-green test and the Hess screen are not widely used by most ophthalmologists, we used the alternate prism-cover test to study the effect of intravenous edrophonium chloride (Tensilon) on the ocular alignment of 30 normal subjects and 14 individuals with nonmyasthenic strabismus. After measurement of their baseline phorias and tropias, patients received an intravenous injection of Tensilon via the incremental dose technique until autonomic effects of the drug were noted or until 10 mg was administered. Another set of measurements of muscle balance was taken immediately postinjection and 2 and 5 min later. Apart from a small increase (mean, 2 prism dipoters; p = 0.004) in their exophoria at near, normal subjects exhibited no significant change in their phorias after Tensilon injection. One third to one half of the nonmyasthenic strabismics, however, showed a change in their vertical deviation after Tensilon (46% at distance and 38% at near), with the majority of them increasing their angle of squint. These changes were small (mean, 1.7 prism diopters; maximum, 5 prism diopters). In only one case did reversal of the direction of deviation occur. Tensilon produces a statistically significant increase in near exophorias of normal subjects and in vertical distance deviations of nonmyasthenic strabismics. These changes, however, are clinically insignificant and should not be considered to constitute a positive Tensilon test.
Subject Adolescent; Adult; Older people; Diagnosis, Differential; Dose-Response Relationship, Drug; Edrophonium/administration & dosage; Edrophonium/diagnostic use; Female; Humans; Infusions, Intravenous; Male; Middle Older people; Myasthenia Gravis/diagnosis; Myasthenia Gravis/physiopathology; Oculomotor Muscles/drug effects; Oculomotor Muscles/physiopathology; Parasympathomimetics/administration & dosage; Parasympathomimetics/diagnostic use; Refraction, Ocular; Strabismus/diagnosis; Strabismus/physiopathology; Vision Tests/methods
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 224790
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jm5gqs/224790