| Identifier |
20220213_nanos_posters_332 |
| Title |
Characterization of VRDN-001, a High Affinity and Potent Anti-IGF-1R Inhibitory Antibody in Development for the Treatment of Thyroid Eye Disease |
| Creator |
Hyunjin Shin, Jung-Won You, Ki-Seok Koh, Wu-Chul Song |
| Subject |
Graves' Disease; Orbit/Ocular Pathology; Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid); Orbit |
| Description |
VRDN-001 is an antagonist antibody to insulin-like growth factor-1 receptor (IGF-1R) under development by Viridian Therapeutics for Thyroid Eye Disease (TED). TED is characterized by recruitment of fibrocytes that express IGF-1R and TSHR into orbital tissues, where they mediate deposition of hyaluronan and expansion of orbital tissues. We evaluated the binding characteristics of VRDN-001 to IGF-1R and its potency for inhibition of IGF-1R phosphorylation. |
| Date |
2022-02 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2022 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2022: Poster Session I: Orbital and Eyelid Disorders |
| Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management |
Copyright 2022. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6zr5t7t |
| Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
| Contributor Primary |
Hyunjin Shin |
| Contributor Secondary |
Jung-Won You, Ki-Seok Koh, Wu-Chul Song |
| Setname |
ehsl_novel_nam |
| ID |
2065352 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6zr5t7t |
