Identifier |
20220213_nanos_posters_332 |
Title |
Characterization of VRDN-001, a High Affinity and Potent Anti-IGF-1R Inhibitory Antibody in Development for the Treatment of Thyroid Eye Disease |
Creator |
Vahe Bedian; Rachel Newell; Barrett Katz |
Affiliation |
(VB) (BK) Viridian Therapeutics, Inc., Waltham, Massachusetts; (RN) Viridian Therapeutics, Inc., Boulder, Colorado |
Subject |
Graves' Disease; Orbit/Ocular Pathology; Neuro-ophthalmology & Systemic Disease (eg. MS, MG, Thyroid); Orbit |
Description |
VRDN-001 is an antagonist antibody to insulin-like growth factor-1 receptor (IGF-1R) under development by Viridian Therapeutics for Thyroid Eye Disease (TED). TED is characterized by recruitment of fibrocytes that express IGF-1R and TSHR into orbital tissues, where they mediate deposition of hyaluronan and expansion of orbital tissues. We evaluated the binding characteristics of VRDN-001 to IGF-1R and its potency for inhibition of IGF-1R phosphorylation. |
Date |
2022-02 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2022 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2022: Poster Session I: Orbital and Eyelid Disorders |
Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
Publisher |
North American Neuro-Ophthalmology Society |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
Copyright 2022. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6zr5t7t |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
2065352 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6zr5t7t |