Walsh & Hoyt: Pathology

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Identifier wh_ch62_p3556_3
Title Walsh & Hoyt: Pathology
Creator Jacqueline Winterkorn, MD, PhD (1947-2015); Rochelle S. Zak, MD
Affiliation (JW) Clinical Professor, Department of Ophthalmlogy, Weill Cornell Medicine; (RSZ) UCSF Medical Center
Subject Encephalitis Lethargica; Pathology
Description The neuropathologic findings in acute EL include inflammation, vasculopathy, and necrosis, consistent with viral infection. The leptomeninges show vascular congestion, with hyperemia and petechiae. Cerebral edema is present. Microscopic features of the acute infection are diffuse perivascular cuffing with lymphocytes and plasma cells. Congestion and minute hemorrhages in gray matter result from destruction of small venules. Diffuse parenchymal inflammation is composed of lymphocytes, plasma cells, and inflammatory nodules. In addition, many specimens show focal meningeal infiltration, neuronophagia, and loss of neurons with release of neuromelanin pigment into the neuropil of the locus ceruleus, cerebellum, ocular motor nuclei, and pars compacta of the substantia nigra. Chronic cases show extensive astrogliosis, especially in frontal and temporal white matter, persistent perivascular infiltrates, and, occasionally, perivascular or intraparenchymal mineralization in the striatum, hippocampus, thalamus, and brainstem.
Date 2005
Language eng
Format application/pdf
Type Text
Source Walsh and Hoyt's Clinical Neuro-Ophthalmology, 6th Edition
Relation is Part of Walsh and Hoyt's Clinical Neuro-Ophthalmology Walsh and Hoyt's Clinical Neuro-Ophthalmology
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Wolters Kluwer Health, Philadelphia
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Rights Management Copyright 2005. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6zs650g
Setname ehsl_novel_whts
ID 186665
Reference URL https://collections.lib.utah.edu/ark:/87278/s6zs650g
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